A method for removing benzopyrene from betel nut tobacco, comprising the following steps: (1) adding betel nut tobacco to an aqueous alkali solution, boiling, washing with water until the washing liquid is clear, and filtering to obtain pretreated areca nut; (2) Add organic solvent and / or inorganic acid solution, perform ultrasonic treatment for the first time, filter, wash with water until no solvent remains, add water, and perform second ultrasonic treatment to obtain ultrasonically treated betel nut tobacco fruit; (3) Add fermentation bacteria liquid, sealed and fermented, washed with water, and dried to obtain the fine-quality betel nut tobacco and fruit. In the method of the present invention, the removal efficiency of benzopyrene is as high as 80.54%, wherein the loss of the main active ingredient arecoline is as low as 5.0%, the threshold value of benzopyrene that can be processed is low, the residual amount of reagents is small, and the flavor of betel nut is less affected; the present invention The method has simple process, low cost, environmental protection, is suitable for industrialized production, fills up the gap in the industry, and has very broad application prospects.