The invention discloses a meridian application therapy drug. According to a formula, the drug comprises the following raw materials: Radix Polygoni Multiflori, Radix Aconiti kusnezoffii, meretrix, Radix Dipsaci, Radix Aconiti, Atractylodes, kadsura pepper stems, asarum, peach kernels, angelica dahurica, safflower, pangolin, eucommia, beautiful sweetgum fruits, native copper, nano-copper powder, jade nano-powder, far infrared ceramic micropowder, natural black mud micropowder, stiff silkworm, loofah sponge, radix clematidis, radix puerariae, combined spicebush root, schizonepeta, rhizome cyperi, radix achranthis bidentatae, radix angelicae pubescentis, parasitic loranthus, peach strip, wicker, elm strip, and sophora japonica strip. The meridian application therapy drug provided by the invention can be applied to the back, the abdomen, the neck or limbs of the human body to make the pharmacological components of the drug effectively absorbed by the human body. And by means of the sensing effect of meridian acupoint stimulation, the meridian application therapy drug can achieve the efficacy of dredging the meridians, dispelling wind and eliminating dampness, adjusting viscera, dredging blood vessel, promoting metabolism, improving the internal environment of the body, exciting the human body disease resistance, improving immunity and increasing the bone mineral density.