The invention discloses a simple synthetic process of an antidepressant medicine imipramine hydrochloride intermediate. The simple synthetic process includes the following steps: (1) putting 6-amino-2-hexanone, BOC anhydride and DCM into a reaction bottle, and stirring the mixture at a room temperature until the raw materials completely react to form a concentrate; (2) adding AIBN and NBS into theconcentrate, heating the AIBN, NBS and concentrate to reflux, keeping the temperature until the reaction is complete, filtering, leaching a filter cake once with DCM, collecting a filtrate, washing the filtrate one with brine, drying the filtrate with anhydrous sodium sulfate, and reducing the pressure for condensation until the filtrate is dry so as to obtain a crude product; and (3) putting thecrude product into tetrahydrofuran, reducing the temperature to a room temperature, adding 60% sodium hydride soaked and washed twice with methyl tertiary ether into a reaction solution in batches, keeping the temperature until the reaction is complete, pouring the mixture into ice water for extraction twice with methyl tertiary ether, combining organic phases, washing the organic phases with brine, drying the organic phases with anhydrous sodium sulfate, increasing the pressure for condensation, and reducing the pressure for rectification to obtain the final product with the purity being 98.5% and the total yield of the three steps being 61.5%. The synthetic process has the advantages of easily available raw materials, convenient operation and high yield.