The invention relates to the technical field of
heparin sodium production, and discloses a process for extracting crude
heparin sodium through
nanofiltration membrane concentration, wherein the process comprises the following steps: S1, carrying out enzymolysis and high-temperature inactivation on animal viscera, and cooling to obtain an inactivated solution; S2, transferring the inactivated solution into a stirrer for stirring, adding an inorganic
settling agent at the same time, and continuously stirring; S3, adding an alkaline material, stirring, and standing; S4, pumping the supernate into a middle
liquid storage tank, filtering a
settling layer through a plate-and-frame
filter press to obtain residual
clear liquid, and pumping the residual
clear liquid into the middle
liquid storage tank; and S5, fully stirring and mixing the
clear liquid in the intermediate
liquid storage tank, filtering out a small amount of suspended matters through a security filter, concentrating through a
nanofiltration membrane, and carrying out
alcohol precipitation and
drying on the concentrated solution to obtain a crude
heparin sodium product. The process is characterized in that an inorganic
settling agent is adopted to remove turbid substances in the inactivated solution, a disc tube type
nanofiltration membrane is adopted to remove salt and small molecular impurities in the clear liquid,
heparin sodium is concentrated, and then the
heparin sodium crude product is obtained through
alcohol precipitation and
drying processes.