The invention discloses a drive control circuit, a drive method, a circuit board and an air conditioner. The motor drive control circuit comprises a first power module, a second power module, a firstswitch group, a controller, a totem-pole PFC circuit and a step-down switch circuit, wherein the first power module and the second power module are connected to two sides of an open-winding motor, thecontroller is connected with the totem-pole PFC circuit to control the totem-pole PFC circuit to reach at least one of the following states: a diode rectification state, a low-frequency switching state and a high-frequency switching state; and a diode rectification mode and a low-frequency switching mode of the totem-pole PFC circuit are matched. The controller controls the step-down switch circuit to carry out step-down output, and provides a voltage suitable for low-frequency operation for the first power module, thereby obtaining a higher energy efficiency ratio in a low-frequency operation state of the open-winding motor, the operation efficiency of equipment at a low frequency is improved, and the energy-saving demands are met.