The invention provides a lock cylinder fixed type mechanical anti-theft lock used for safes, and relates to the field of anti-theft locks. The lock cylinder fixed type mechanical anti-theft lock mainly aims at solving the problem that the related patented technology with a lock cylinder fixed type cross mechanical anti-theft lock as the core cannot be directly used together with the large safes ina matched manner. According to the scheme, a cam mechanism in the core technology mentioned above is omitted and is replaced with a lock block capable of reciprocating, the special structure of the lock block has the control effect, the same as that for the cam mechanism, for a lock cylinder set, and a jamming effect can be achieved for a lock bolt drive and transmission device by movably inserting a clamping pin, arranged on the lock drive and transmission device, in the lock block; during unlocking, unlocking is driven through wheel handles of overload protection devices arranged on the safes themselves, and keys can still only be inserted and pulled and cannot be rotated; and the existing patent core technology mentioned above and functions are not changed, the safety performance of the new product is remarkably improved, the lockset structure is substantially simplified, cost is low, and performance is stable and reliable.