The invention provides an anti-skid and anti-electric shock sole and a manufacturing method thereof. According to the formula, the anti-skid and anti-electric shock sole is prepared from polyisoprenerubber, styrene-butadiene rubber of solution polymerization, acrylonitrile-butadiene-styreneterpolymer, mineral oil, zinc oxide, vulkanox, activated calcium carbonate, bis(2-ethylhexyl)adipate, tackifying resin, stearic acid, polyethylene glycol, a silane coupler, polyethylene wax, insoluble sulfur powder, vulcanization accelerators and antiskid auxiliary agent. The acrylonitrile-butadiene-styreneterpolymer are added to the sole formula, the anti-electric shock performance of the sole is enhanced, after repeated tests, the maximum leakage current at 18kVA voltage does not exceed 0.5mA, is farbeyond the industry standard, and can enhance the protection of users; the added antiskid auxiliary agent effectively improves the antiskid performance of the sole, measured by a plurality of tests,the anti-slip coefficient increases to 0.88, and so as to safety risks are further reduced when users work on the electricity.