The invention belongs to the technical field of traditional Chinese medicine preparation, and discloses a compound bone arthralgia plaster medicine, a preparation method and application. The compoundbone arthralgia plaster medicine comprises the following components according to weight: 20 g of garden balsam stem, 20 g of lycopodium clavatum, 20 g of Chinese angelica, 20 g of notopterygium root,15 g of radix angelicae pubescentis, 25 g of lithospermum, 10 g of asarum, 20 g of cassia twigs, 10g of radix aconite, 10 g of radix aconiti kusenzoffii, 20 g of radix clematidis, 15 g of golden cypress, 20 g of radix angelicae, 15 g of prepared frankincense, 15 g of prepared myrrh, 15 g of carthamus tinctorious, 10 g of arisaema heterophyllum blume, 10 g of stiff silkworm, 10 g of raw nux vomica,15 g of ephedra and 20 g of radix stephaniae tetrandrae. According to the compound bone arthralgia plaster medicine provided by the invention, the affected parts are locally and directly stimulated through point application therapy, the efficacy of the medicine directly reaches the affected parts, the therapy is more targeted, the part selection is accurate, the duration is long, the curative effect is definite, the medicine is safe and free of wound, and the medicine has the advantages of being simple, economical and practical and can be widely applied clinically.