The invention provides a treatment process of nickel-containing alloy powder in a hydrochloric acid system. The treatment process comprises the following steps that (1) presoaking of the nickel-containing alloy powder is carried out, specifically, the nickel-containing alloy powder, concentrated hydrochloric acid and water are mixed, and then heated, stirred and presoaked; (2) high-pressure oxygen introduction and leaching is carried out, specifically, prepreg is poured into a high-pressure kettle, heating is carried out, oxygen is introduced to react for a certain time, cooling and liquid-solid separation are carried out, leaching residues are produced and stacked, and leaching liquid enters a next process; (3) neutralization and impurity removal are carried out, specifically, the pH value of the leaching liquid is adjusted by using nickel carbonate, a neutralization solution and neutralization slag are produced, and the neutralization slag returns to the leaching process; (4) cobalt extraction with resin is carried out, specifically, cobalt ions in the neutralization solution is adsorbed with the resin to produce cobalt carbonate precipitate and cobalt-extracted liquid; and (5) product preparation is carried out, specifically, nickel carbonate is prepared from a small part of cobalt-extracted liquid for a neutralization and impurity removal process, the rest liquid is concentrated and pyrolyzed, hydrochloric acid is produced for recycling, and nickel oxide is taken as a final product. According to the treatment process, the nickel oxide product is produced through the leaching, purifying and pyrolyzing processes, meanwhile, hydrochloric acid and a neutralizing and impurity-removing reagent are recycled, and the treatment process is clean and environmentally friendly.