The invention discloses a 
bridge type input resistance negative feedback CMOS (Complementary 
Metal Oxide Semiconductor) pre-amplifying circuit, which consists of an input part and an amplification part, wherein the input part is directly coupled with the amplification part. According to the circuit, a balance 
bridge type input structure is adopted for the input part, 1 kilo-
ohm bias resistance is adopted for each of two 
branch circuits of the input part, one 
branch circuit is connected with a 
detector to form a path, the other 
branch circuit is connected with a blind pixel to form another path, and the two paths form the balance 
bridge type input structure; in order to meet the requirements of different amplification factors and achieve adaptability to the amplification readout of 
detector signals with different response ratios, a variable 
gain resistance 
negative feedback structure is adopted for the amplification part, selectable 5, 2 or 1 meg-
ohm feedback resistance is adopted between the negative input end and the output end of the amplification part, and feedback resistances with different magnitudes are formed under the control of two MOS switches; in order to enable the circuit to work at low temperature of 
liquid nitrogen, a common-source common-gate structure is adopted for a 
differential amplifier in the amplification part, and the 
differential amplifier is powered by positive and 
negative power supplies.