The invention provides an organic and inorganic slow-release compound fertilizer and a preparation method thereof, and relates to the technical field of chemical fertilizers. The organic and inorganic slow-release compound fertilizer comprises potassium sulfate, humic acid, monoammonium phosphate, thiamine, urea and a slow-release agent. The preparation method comprises the following steps: preparing materials, batching materials, mixing, granulating, drying, cooling, sizing, enveloping membranes, packing and entering warehouse. The chemical fertilizer provided by the invention can enable active ingredients to be released slowly and gradually, the fertilizer consumption is reduced, the utilization rate is improved, the construction is convenient, the labor is saved, the safety is achieved, the soil environment is improved, and the soil looseness degree is improved.