The present invention discloses an active biological drug fertilizer, which is characterized in that: the present invention is prepared with the fermenting process by photosynthetic bacteria, yellow corrupted acid and the extraction from Azadirachtin, Langdu Root and kusnezoff monkshood. The present invention is with an especial function for killing insect and preventing disease as well as accelerating the growth for the plant, protecting flower and fruit, enhancing the output and improving the integrative performance for the product quality and so on. The present invention is adaptable to the crops including rice, wheat, cotton, cole, bean, earthpea, corn, bast fibre plants, watermelon, fruit tree, vegetable, tobacco leaf, tea leaf, medicinal materials, flower, and pasture and seeding wood and so on. Besides, the present invention has also the function for accelerating the output for the pecan. The prevention and cure objects include: lepidopterans, orthopteran, Diptera, Coleoptera, ring vein, Hymenoptera and acarid and so on. The present invention has the much higher sensitivity to the following pests including: prodenia litura, asparagus caterpillar, cabbage butterfly, tea geometrid, tea smaller green leaf hopper, pecan peachblossom maggot and locust and so on.