The invention discloses a low-grade mineral separation process, and relates to the technical field of mineral separation. The process comprises the following steps that coarse crushing operation is conducted on ores in a raw ore bin to obtain coarse crushed products, the coarse crushed products are fed into a vibrating screen for screening, undersize products return to a cone crusher for fine crushing operation, then the undersize products are fed into the vibrating screen, oversize products fall into a fine ore bin, materials in the fine ore bin are fed into a high-pressure roller mill, and the materials are fed into a ball mill A through a feeding chute; ball-milling discharged ore is conveyed to a linear screen, the undersize products sequentially enter two nelson concentrators for reselection, and the oversize products return to the ball mill A for regrinding; and the reselected concentrate enters a Nelson table concentrator for concentration and then is subjected to flotation operation, the flotation concentrate is sold to a smeltery, the tailings enter a reselection workshop for reselection through the table concentrator, the table concentrator concentrate is a final product of the tailings reselection workshop section and returns to a ball mill B for regrinding through a hose pump, and the chute tailings and the table concentrator tailings are classified through a cyclone, subjected to sand setting and discharged to the underground for filling operation; According to the process, the ore grinding effect is good, and the ore grinding process handling ability and the ore grinding index are improved.