The invention belongs to the technical field of fasteners, and discloses a multi-adaptability U-shaped fastening device. The multi-adaptability U-shaped fastening device comprises a U-shaped bolt group, a gear shifting piece, groovepieces, sliding blocks and a gear bolt, the top surface of the middle of a U piece protrudes upwards, the bottom surface of the U piece forms a blocking groove, a penetrating screw hole is formed in the center of the top surface of the blocking groove, two upper radial grooves are symmetrically formed in the positions, on the two sides of the screw hole, of the topsurface of the blocking groove, the gear shifting piece is arranged in the blocking groove, penetrating beveled grooves are formed in the tops of the two ends of the gear shifting piece correspondingly, a penetrating circular arc circumferential groove is formed in the top of the middle of the gear shifting piece, and the groove pieces matched with the outer contour of the U piece are arranged under the U piece. The sliding blocks capable of being adjusted and retracted through an electric wrench are arranged on the U-shaped bolt group, and the fastening effect is stable; and rubber brackets arranged on the end surfaces of the sliding blocks deform along with the surface of a restrained object, friction on the surface of the restrained object is increased, axial constraining force is increased, when the rubber brackets act on a vertical tubular object, baffle brackets fixed to the rubber brackets in a fit mode has the certain loading capacity, and the stress damage to the surface of therestrained object is small.