12 results about "Isocyanide compound" patented technology

The invention discloses a phenanthridine-6-formaldehyde derivative and a preparation method and application thereof.The preparation method comprises the steps that 2, 4, 5, 6-tetra (9-carbazolyl)-isophthalonitrile serves as a photocatalyst, 1-azabicyclo [2.2. 2] octane serves as a hydrogen atom transfer catalyst, a biphenyl isocyanide compound, the photocatalyst, the hydrogen atom transfer catalyst and an alkali additive are jointly dissolved in 1, 3-dioxolane, the mixture is stirred to be uniform, and the phenanthridine-6-formaldehyde derivative is obtained. And carrying out free radical tandem cyclization and acid-catalyzed hydrolysis reaction to obtain the phenanthridine-6-formaldehyde derivative. The invention also provides a specific reaction equation. According to the developed synthesis method of the phenanthridine-6-formaldehyde derivative, the compound can be efficiently and conveniently prepared, the technical bottlenecks of harsh reaction conditions and tedious steps in a traditional process are successfully overcome, raw materials which are low in price and easy to obtain are adopted, operation is carried out under mild conditions, the synthesis method has the outstanding advantages of being high in yield, safe and simple to operate, environmentally friendly and the like, and the method is suitable for industrial production. Good industrial application potential is shown.

The invention discloses a 2, 3-disubstituted indole derivative and a preparation method thereof, and belongs to the technical field of organic synthesis. The 2, 3-disubstituted indole derivative can be obtained by taking a benzylallenitrile compound and an aryl isonitrile compound as substrates, adding the substrates into a solvent, and carrying out a heating reaction. According to the method, 2-(4-methylbenzylidene) malononitrile and 4-methoxyaryl isonitrile are subjected to a nucleophilic reaction to generate a three-membered ring intermediate, then the three-membered ring intermediate is subjected to a Friedel-Crafts reaction, ring opening is performed, and the 2, 3-disubstituted indole derivative is finally obtained. Indole does not need to be used as a reaction substrate, simple and easy-to-obtain isonitrile and 2-(4-methylbenzylidene) malononitrile are subjected to an alkylation reaction, and a novel simple and efficient synthesis method is provided for de novo synthesis of the 2, 3-disubstituted indole derivative.

The invention discloses a poly (imino selenazoline) compound as well as a synthesis method and application thereof, and the synthesis method comprises the following steps: synthesizing diselenide from elemental selenium, amine and isonitrile, and polymerizing the diselenide and alpha-bromoacetophenone to synthesize the poly (imino selenazoline) compound. And a one-pot, two-step and four-component series polymerization strategy of elemental selenium, amine, isonitrile and alpha-bromoacetophenone is developed to construct the poly (imino selenazoline) compound in situ. The structures of the amine compound, the isonitrile compound and the alpha-bromoacetophenone compound are adjustable, and the polyimidoselenazoline compounds with different structures can be obtained along with the change of the monomer structures. The synthesis method does not involve a catalyst, has the characteristics of mild reaction conditions and simple process, and solves the problems of harsh reaction conditions, tedious steps, low reaction efficiency, non-specific product structure and the like in the synthesis process of the heterocyclic polymer through a multi-component tandem polymerization method.

This invention belongs to the field of mineral processing collector technology, specifically relating to a collector for ilmenite flotation, its preparation method, and its application. The collector comprises a composite collector, a nonionic surfactant, a fatty acid, and a composite inhibitor; the composite inhibitor is composed of modified carboxymethyl cellulose and nano-cerium dioxide; the preparation method of the modified carboxymethyl cellulose is as follows: carboxymethyl cellulose is activated in a dielectric barrier discharge cold plasma device to obtain activated carboxymethyl cellulose; the activated carboxymethyl cellulose is dissolved in water to obtain a carboxymethyl cellulose solution, and then dihydroxyacetone and cyclohexyl isocyanate are added sequentially to the solution and stirred to obtain modified carboxymethyl cellulose. The composite collector and composite inhibitor of this invention work synergistically to improve the grade of titanium concentrate and increase the recovery rate, exhibiting strong collecting ability and good selectivity, and can be used for large-scale production.

The invention discloses a preparation method of a thiocarbamate compound. According to the method, an isocyanide compound and a sulfinic acid compound are used as raw materials, and a series of target products are conveniently prepared under the condition of an oxidizing agent. The method disclosed by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, very simple reaction system, convenience in operation, good substrate universality, high target product yield, safe production and environmental friendliness, and is suitable for industrial production. According to the process, sulfinic acid compounds are used as raw materials, so that the unpleasant smell of thioether and mercaptan and the hidden danger of safe production in the prior art are avoided; meanwhile, a series of problems that thiosulfonate, sulfonyl hydrazide and the like need to be prepared in advance, the technological process is tedious and the like are solved.

The invention relates to the technical field of polymer chemistry, in particular to a poly (imino thiazoline) compound as well as a synthesis method and application thereof. According to the invention, elemental sulfur, an amine compound, an isonitrile compound, an organic solvent and an alpha-bromo-ketone compound are used as raw materials for in-situ construction of the polyimidothiazoline compound. The structures of the amine compound, the isonitrile compound and the alpha-bromo-ketone compound are adjustable, and the polyimidothiazoline compounds with different structures can be obtained along with the change of the monomer structures. The synthesis method does not involve a metal catalyst, has the characteristics of mild reaction conditions and simple process, and solves the problems of harsh reaction conditions, tedious steps, low reaction efficiency, non-specific product structure and the like in the heterocyclic polymer synthesis process through a multi-component tandem polymerization method.

Disclosed is a compound of formula (I) or (II) 1 , Y 2 and Y 3 CR 1 or N]. Such compounds are used as antibiotics and antifungals.

We report the synthesis, characterization, and catalytic activity of a family of thermally stable dinuclear Ni(I) complexes supported by commercially available isocyanides as a general solution to this problem. Two classes of Ni(I) isocyanide complexes showing high thermal and solid-state stability have been developed – coordinatively saturated homoleptic compounds and coordinatively unsaturated Ni(I)-halide compounds. The Ni(I) compounds exhibit rapid ligand substitution and are efficient catalysts in Kumada, Suzuki-Miyaura, and Buchwald-Hartwig cross-coupling reactions, suggesting their potential use as either Ni(I) catalysts or pre-catalysts. In addition, bromide-selective functionalization of polyhalogenated arenes with Grignard reagents was achieved for the first time under nickel catalysis. Finally, spectroscopic and mechanistic studies were performed to establish the general use of simple isocyanide ligands as spectator ligands for cross-coupling reactions, representing an untapped chemical space for new reaction discovery.

The present invention discloses a method for photocatalytic synthesis of 6-methylphenanthridine compounds, comprising the following steps: dissolving a biphenyl isocyanide compound in a dimethyl sulfoxide solvent, adding a photosensitizer and a base, reacting at room temperature for 24 hours under blue light irradiation, and after the reaction is completed, column chromatography is performed to separate and obtain 6-methylphenanthridine compounds. The raw materials used in this preparation method are cheap and easy to obtain, the reaction system is mild, the operation is simple, and the yield is high. 6-methylphenanthridine compounds have a wide range of uses and can also be used as a synthetic intermediate.

The present invention belongs to the field of chemical drugs, and specifically relates to a series of 2,4-disubstituted 4H-benzo[d][1,3]oxazine compounds, a preparation method thereof, and an application thereof. The present invention adopts a preparation method for directly synthesizing a series of 2,4-disubstituted 4H-benzo[d][1,3]oxazine compounds by directly reacting an o-acylaryl isocyanide compound with a radical initiator azobisisobutyronitrile (AIBN) under the conditions of metal-free, catalyst-free, and base-free. The preparation method has simple and mild reaction conditions, high safety, high product yield, low raw material cost, and does not require the use of any catalyst and alkali solution, and is more suitable for industrial production. The series of 2,4-disubstituted 4H-benzo[d][1,3]oxazine compounds prepared by the present invention have potential biological activities and medicinal values, and can carry out gram-scale reactions.

The application provides a polysiloxane containing a side group of an alpha-amidoamide structure and a preparation method and application thereof, the polysiloxane is prepared from a polysiloxane containing a carboxyl side group, a primary amine, a monohydric aldehyde and an isocyanide compound, has a linear structure with a side group of an alpha-amidoamide, the side group includes aliphatic and aromatic groups and the like, and the structure is unique, the polysiloxane containing the side group of the alpha-amidoamide structure can be further crosslinked into a polar organosilicon elastomer as a prepolymer, the glass transition temperature and the dielectric constant of the organosilicon elastomer are obviously improved, meanwhile, the organosilicon elastomer has excellent mechanical properties, has a good application prospect, and further widens the application range of the polysiloxane.

The present invention relates to a method for preparing imidazopyridine compounds by using Cu-W2C / AC to catalyze lignin and model compounds, specifically a new method for one-step catalytic conversion of lignin β-O-4 model compounds or lignin raw materials into imidazopyridine heterocyclic chemicals by using Cu-W2C / AC as a catalyst, N,N-dimethylformamide as a reaction solvent, and amino pyridine compounds and isocyanide compounds as nitrogen sources. The present invention uses renewable biomass resources as raw materials, which are cheap and widely available; inorganic acids and bases are not required during the reaction process; the reaction conditions are mild, the yield of the target product is high, and the catalyst can be recycled, providing a new route for preparing high-value-added imidazopyridine heterocyclic chemicals from lignin.