The invention discloses composition having effects of clearing heat and removing toxins. The composition is prepared from raw materials in parts by weight as follows: 15-20 parts of loquat leaves, 15-20 parts of prepared rehmannia roots, 10-15 parts of dried rehmannia roots, 10-15 parts of dwarf lilyturf tubers, 10-15 parts of cochinchinese asparagus roots, 10-17 parts of immature bitter oranges, 8-10 parts of virgate wormwood herbs, 8-13 parts of dendrobium nobile, 10-15 parts of liquorice roots and 10-13 parts of baical skullcap roots. The composition has effects of clearing heat and removing toxins, has functions of removing internal heat of stomach and intestines, activating blood and invigorating the stomach, is used for treating stasis-heat in the stomach, bad breath, sore throat, sores in mouths, oral ulcer, gingival abscess, pharyngolaryngitis, tongue cancer, scurvy, jaundice and the like, has a heat clearing and detoxication function on chronic stomatitis, oral ulcer and perioral cellulitis and has the curative effect commonly superior to that of a conventional anti-bacterial and anti-inflammatory drug.