The invention discloses a pressure-regulating and mold-filling high-pressure solidification casting device and casting method. The device comprises a smelting furnace, an injection rod, a riser tube,a hammer head, a charging barrel, a mold, a vacuum tube and a vacuum stop valve. By means of the device, a high-quality aluminum alloy melt can be taken from the center of molten aluminum in a smelting furnace, the molten aluminum is conveyed into a mold cavity through the closed liquid riser tube and a charging barrel by controlling a pressure difference between the interior of the smelting furnace and a mold cavity by a computer, and the molten aluminum level stably rises in the whole process, so that the contact area between molten aluminum and air in the conveying and mold filling stages is greatly reduced, oxidizing slag is reduced, and meanwhile, a certain vacuum condition is formed in the mold cavity, so that the air content of the molten aluminum is reduced, and the mold filling capacity of the molten aluminum in the mold cavity is improved. After mold filling is completed, a casting is solidified under a high pressure, the casting is compact in structure and fine in grain, theforming probability of casting defects such as shrinkage porosity, shrinkage cavities and pinholes is greatly reduced, and finally the internal quality of the casting and the mechanical property of abody are greatly improved.