The invention discloses processing equipment with good dustproof effect for semiconductor device manufacturing. The equipment comprises a supporting plate, supporting frames are bolted to the front surface and the back surface of the top of the supporting plate, a processing box is bolted to the tops of the supporting frames, a dustproof mechanism is arranged in an inner cavity of the processing box, and a dust collection mechanism matched with the dustproof mechanism for use is arranged at the top of the inner cavity of the processing box. According to the equipment, through cooperation of a first air pump, a hose, a second motor, a driving gear, a first driven gear, a second driven gear, fixing pipes, a connecting pipe, a U-shaped pipe and a nozzle, a user can conveniently use the second motor to drive the two groups of the fixing pipes to rotate at the same time, so that the inner cavity of the processing box is blown in all directions through the rotating nozzle, furthermore, dust in the processing box is always in a floating state, and through cooperation of a second air pump, a ventilation pipe, a flow dividing pipe, a diffusion pipe, a pipeline and suction heads, the user can conveniently use the second air pump to drive the multiple suction heads to rapidly absorb the floating dust.