The invention discloses a loop heat pipe with a multi-scale structure synergistic mixed wettability inner surface. All parts are sequentially connected in series to form a cycle, the interior of the loop heat pipe is provided with the multi-scale structure synergistic mixed wettability inner surface, and the loop heat pipe comprises an evaporator, a condenser, a steam line and a liquid line, and the evaporator is provided with a multi-scale capillary core with gradient hydrophilicity and hydrophobicity. The size is gradually reduced in the circulation direction, the surface is transited from hydrophobicity to hydrophilicity, hydrophobic points are arranged in a hydrophilic area, and hydrophilic points are arranged in a hydrophobic area. The condenser is provided with a multi-scale micro-column inner surface with gradient hydrophobicity, the surface of a nanoneedle transits from super hydrophobicity to hydrophobicity in the circulation direction, and the top end of the embedded micro-column is hydrophilic and forms a hydrophilic point. The steam line and the liquid line are reducing pipes, the pipe diameter and the size of the porous structure on the inner surface are gradually reduced in the circulation direction, and gradient wettability is achieved. By means of the reasonably-designed cooperation mode of the surface multi-scale structure and the mixed wettability, the requirements of different areas and stages of the loop heat pipe for the structure scale and wettability can be met, and the heat exchange performance of the loop heat pipe is improved through all-around cooperation.