The invention provides a single-component polyurethane foam joint mixture and a preparation method thereof, and is characterized in that the single-component polyurethane foam joint mixture comprises the following raw material components: 15-22 parts of mixed polyether, 1.4-2.8 parts of silicone oil, 14-17 parts of environment-friendly paraffin, 0.6-1.2 parts of a catalyst, 2-4 parts of an insecticide, 2-6 parts of a degradation agent, 1.5-4.5 parts of a slow-release fertilizer, 0.5-1.5 parts of an aging color indicator, 38-40 parts of polymerized MDI, 14-18 parts of a propellant, and 1-3 parts of CO2. The invention has the advantages that: 1, the product is applied to insecticides, so that corresponding agricultural crops and plants are prevented from being damaged by pests; 2, a compound fertilizer is added, so that the fertilizer has the characteristic of accurate and comprehensive fertilization, the fertilizer utilization rate is increased, and the crop yield is increased; 3, a related degradation agent is added, so that the product is quickly and naturally degraded, and the cleaning cost after use is reduced; and 4, aerosol packaging is adopted, so that the requirements of modern agriculture are met, and the product is safe to preserve and good in storage stability. The invention also discloses a preparation method of the single-component polyurethane foam joint mixture.