The invention discloses flue-cured tobacco cadmium-reducing organic fertilizer based on cow dung and a preparation method and application thereof. The flue-cured tobacco cadmium-reducing organic fertilizer comprises cow dung, potassium dihydrogen phosphate, sodium selenite, furnace slag, calcium carbonate, magnesium sulfate and sulfuric acid according to a certain ratio. The preparation method comprises A, stack retting decomposition of cow dung, potassium dihydrogen phosphate and sodium selenite, B, furnace slag preparation, and C, preparation of enough amounts of other three commodity raw materials and furnace slag raw materials prepared through the step B based on the mass of the cow dung matrix in step A, and uniform stirring of the raw materials and a stack retting decomposition raw material prepared through the step A so that the flue-cured tobacco cadmium-reducing organic fertilizer is obtained. The flue-cured tobacco cadmium-reducing organic fertilizer has a simple formula. Thepreparation method is easy and is easy to operate. The product satisfies the national organic fertilizer standards, significantly passivates the soil cadmium activity, reduces flue-cured tobacco cadmium accumulation, reduces the soil active cadmium by 28.8-44.9% and flue-cured tobacco cadmium content by 18.8-50.3%, especially reduces the cadmium in the upper leaves by 42.9-50.3% and has a large promotion and application value in the heavy metal-polluted tobacco areas such as cadmium-polluted tobacco areas.