56results about How to "New route" patented technology

The invention provides a new strain-Rhodococcus sp. ZJPH1003 and an application thereof in preparing S-(+)-2,2-dimethylcyclopropane carboxylic acid through microbial catalytic asymmetric hydrolysis of 2,2-dimethylcyclopropane ethyl formate. The strain is conserved at China Center for Type Culture Collection, the conservation address is Wuhan University, Wuhan, China, postcode 430072, the conservation number is CCTCC M 2010371, and the conservation date is December 29, 2010. In the invention, the adopted method for preparing the S-(+)-2,2-dimethylcyclopropane carboxylic acid through microbial catalytic asymmetric hydrolysis of the 2,2-dimethylcyclopropane ethyl formate by utilizing the new microbial strain has the advantages of novel route, high yield, environmental friendliness and the like; and by utilizing a chiral biocatalysis method which takes a Rhodococcus ZJPH1003 cell as a catalyst, for the target product-S-(+)-2,2-dimethylcyclopropane carboxylic acid, the e.e can reach 82.5% and the yield can reach 41.3% when the substrate concentration is 30mmol / L.

The invention discloses a preparation method of pitavastatin calcium intermediate, comprising the following steps: (4R-Cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4 The sulfonylation reaction of tert-butyl acetate and p-toluenesulfonyl chloride under the action of a catalyst gives (4R-Cis)-6-p-toluenesulfonyl-2,2-dimethyl-1,3-dioxane- 4-tert-butyl acetate; then react with trimercapto-s-triazine under the action of a basic catalyst to obtain substance A; then oxidize to obtain substance B through the action of an oxidizing agent; finally react with 2-cyclopropyl-4-(4-fluorophenyl ) quinoline-3-formaldehyde is reacted under the catalysis of sodium hydride to obtain pitavastatin calcium intermediate. The raw material of the present invention is cheap and easy to obtain, good atom economy, green and environmental protection, mild and controllable reaction conditions, simple operation, simple purification treatment, suitable for industrial production, good stereoselectivity, high yield, and the prepared pitavastatin calcium intermediate Good purity.

The invention provides a preparation method for a key intermediate (I) of letrozole. According to the method, 2-(4-cyanophenyl)formylformic acid (II) and 4-halogenated cyanophenyl (III) are used as raw materials and subjected to one-step reaction in the presence of alkali, a solvent and a catalyst so as to generate a target product. The preparation method is novel in route, simple and controllable in operation, high in reaction yield, economical and capable of ensuring that high-purity letrozole is obtained through subsequent preparation, and provides guarantees for industrial large-scale production of high-purity letrozole.