The invention discloses a manufacturing method of a blind-hole compressor impeller. The manufacturing method comprises the following steps: step 1, installing an impeller blank on a numerical-control vertical lathe, turning the bottom end surface, a bottom end outer circle, a back arc and a large outer circle, and machining a blind hole by utilizing a reamer; step 2, clamping the large outer circle by utilizing three claws, leveling the bottom end surface, and turning a meridian plane and a top end surface; step 3, locating by utilizing the bottom end surface, connecting a bolt with the blind hole by threads, straining the bolt, clamping the back arc and the bottom end outer circle by utilizing a clamp, machining a threaded hole, and milling an inner hexagonal hole, blades and runner. By adopting the manufacturing method, the machining precision can be guaranteed, the production efficiency is improved, and the manufacturing cost is reduced.