The invention discloses a lubricant for a hot extrusion molding titanium alloy pipe as well as a preparation method and application thereof, which belongs to the field of lubricants and preparation thereof, and aims to solve the technical problems of poor fluidity and easy peeling and cracking of the existing glass lubricant in the extrusion lubrication process. The lubricant for the hot extrusionmolding titanium alloy pipe is prepared from the following components in parts by mass: 35 to 45 parts of SiO2, 2 to 4 parts of Al2O3, 18 to 28 parts of B2O3, 17 to 21 parts of Na2O, 5 to 8 parts ofCaO, 1 to 5 parts of MgO, 1 to 8 parts of BaO, 1 to 5 parts of ZnO and 1 to 2 parts of LiO. The preparation method comprises the following steps of 1, uniformly mixing materials according to a formula, and then heating and smelting to obtain molten glass, and 2, pouring into cold water, carrying out cold quenching, drying, carrying out ball milling, drying, and screening to obtain the lubricant. The lubricant can be used as a lubricant for hot extrusion molding of titanium alloy pipes. After the TC4 titanium alloy coated with the lubricant coating is extruded, the surface of a pipe is integrally smooth, other obvious defects such as longitudinal and transverse scratches are avoided, and the overall surface quality is superior to the surface quality of the pipe extruded by a lubricant in the traditional process.