The invention provides a semiconductor packaging structure, which comprises a substrate, a first chip, a first lead, a second adhesion layer, a second chip, a second lead, a first packaging body, a second packaging body and a conducting element, wherein the substrate is provided with a front and a back, and is also provided with an opening penetrating the substrate; the first chip is provided withan active surface and a back, covers the opening through a first adhesion layer in a mode that the active surface is upwards, and is attached to the back of the substrate through the first adhesion layer; the first lead is electrically connected with the first chip and the front of the substrate through the opening; the second adhesion layer coats the first lead and covers a solder pad on the active surface of the first chip and partial front of the substrate; the second chip is provided with an active surface and a back, the back of the second chip is downwards and the active surface is upwards relative to the first chip, and the second chip is attached to the front of the substrate through the second adhesion layer; the second lead is electrically connected with the active surface of the second chip and the front of the substrate; the first packaging body coats the first chip, the first adhesion layer, the first lead and partial back of the substrate; the second packaging body coststhe second chip, the second adhesion layer, the second lead and the partial front of the substrate; and the conducting element is arranged on the back of the substrate.