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The application provides a bimetallic nanoparticle-based acetone gas sensor and a preparation method thereof. The preparation method comprises the following steps: adding tin chloride into a solution containing a complexing agent and deionized water, stirring for 10 minutes at 60 DEG C, then adding ammonia water until the pH reaches 3, and obtaining a tin hydroxide precipitate powder after centrifugal washing; adding the tin hydroxide precipitate powder into indium trichloride tetrahydrate powder, gold chloride powder and platinum tetrachloride powder in sequence, and performing ball milling mixing, sintering at 600 DEG C for 2 hours, and obtaining bimetallic nanoparticle; adding ethylene glycol and zirconium oxide ball milling beads into the bimetallic nanoparticle, performing ball milling for 8 hours, obtaining a point glue solution, coating the point glue solution on a micro motor heating plate, drying at room temperature, and sintering at 200-400 DEG C for 3-4 hours, and obtaining the bimetallic nanoparticle-based acetone gas sensor. Therefore, the excitation temperature can be effectively reduced, and the selectivity to acetone gas can be improved.