In some aspects, the disclosed technology generally relates to a
system configured for detection of a transition in
thermoregulation. In some embodiments, the
system may include at least one sensor configured to measure a plurality of
heat flux measurements of a subject over time; a processor configured to receive the plurality of
heat flux measurements over time, characterize the relationship between
heat flux and temperature over time, and detect a transition from a first thermoregulatory control state to a second thermoregulatory control state prior to an onset of fever or infection; and an indicator prompting proposed intervention prior to the onset of fever or infection. The disclosed technology also generally relates, in certain embodiments, to systems for the
early detection of fever, particular in
sepsis patients, and methods of detecting health anomalies in
sepsis patients.