The invention discloses a preparation method of 
polyurethane prepolymer with low free 
isocyanate monomer. The preparation method comprises the following steps of: forming into mixed 
alcohol by trihydric 
alcohol and dihydric 
alcohol under the temperature of 120-150DEG C, and carrying out vacuum 
dehydration; putting 
isocyanate monomer and ester solvents into a reactor to keep the temperature at 30-70DEG C, and dropwise adding the mixed alcohol into the reactor; after dropwise adding, continuously reacting for 3-6h under the temperature of 40-70DEG C under stirring, and discharging in a cooling way to obtain 
polyurethane prepolymer; and separating the obtained 
polyurethane prepolymer, and adjusting the 
solid content of polyurethane prepolymer 
solid and the content of free 
isocyanate monomer in the separated heavy components by diluted 
solvent. According to the preparation method, the real 
continuous production can be realized, all the recovered 
solvent and isocyanate monomer can be recycled, the 
zero emission can be realized, and the real clean production can be realized; and the product has the characteristics of being low in 
viscosity, high and adjustable in NCO value content, low in the content of the free isocyanate monomer, high in 
solid content, good in compatibility, etc.