The invention relates to an environment friendly microwave medium ceramic substrate which is mainly used for the circuits of microwave and millimeter wave satellite communication products, military radar products, electronic navigation products, microwave safety monitoring products, and the like. The substrate is prepared by adopting the following steps of: directly mixing ceramic microcrystal powder with polytetrafluoroethylene (PTFE) powder, PTFE emulsion, glass fiber powder, liquid-state epoxy resin and PVA (Polyvinylalcohol) solution raw material and micro flame-retardant additive raw materials: brominated resin, antimony pentoxide (Sb2O5) and bismuth trioxide (Bi2O3); carrying out blooming, primary drying, laminating, finish rolling, two-surface or two-way continuous sizing, redrying, two-surface or two-way continuous copper foil coating, tailoring and high-pressure lamination; then vacuumizing and curing for 50-60min at low temperature of 170-200 DEG C. The invention does not contain Nb heavy metal components and has good properties of microwave high frequency band low dielectric Epsilonr, low loss tan delta, high signal transmission efficiency and high stability and the advantages of simple process and low sintering temperature and can be cofired with a silver electrode.