The invention discloses a compound fertilizer special for dragon fruit, and a preparation method and an application thereof, and belongs to the technical field of the fertilizers and the preparation methods thereof. The compound fertilizer special for the dragon fruit is prepared from the following components by weight percent: 40-90% of organic fertilizer, 40-49% of inorganic chemical fertilizer, 4-6% of humic acid, 0.5-1.5% of nutritional additives, 5-7% of composite binder and 0.4-0.7% of conditioner. Due to optimized combination of the organic fertilizer, the inorganic fertilizer, major elements and trace elements, the dragon fruit can be enabled to bloom and bear fruits early, the yield of the dragon fruit can be increased, and the quality of the dragon fruit also can be improved. Due to organic-inorganic combination, complete nutrition is provided for the growth of the dragon fruit, and the soil structure can also be modified easily, the utilization rate of the fertilizer is increased, and the yield and the quality of the dragon fruit can be improved remarkably; in the meantime, the compound fertilizer also has the advantages that the agricultural wastes are recycled and the preparation cost of the fertilizer is low, and therefore, the compound fertilizer is excellent in economic benefit and ecological environmental benefit.