The invention relates to a high-wear-resistance high-accident-resistance secondary intermediate roll. The secondary intermediate roll is prepared from (1) 12-15 parts of C, (2) 2-6 parts of Si, (3) 2-5 parts of Mn, (4) 100-110 parts of Cr, (5) 8-12 parts of Mo, (6) 7-10 parts of V, (7) 3-5 parts of Co, (8) 1-3 parts of silicon-copper master batch wear-resistant agents, (9) 0.2-0.3 part of P, (10)0.2-0.3 part of S, and (11) 800-1000 parts of Fe and inevitable impurities. The preparation method of the secondary intermediate roll comprises the steps of (1) performing refining, pouring into ingots, electroslag remelting, forging forming according to chemical composition and weight fraction to make a rough billet, (2) conducting forging and spheroidizing annealing treatment on the rough billetto obtain a steel billet; (3) conducting rough turning and modulation treatment on the steel billet; (4) conducting quenching heat treatment on the steel billet; (5) conducting tempering treatment onthe steel billet; (6) performing refining; and (7) performing surface acoustic wave detection. According to the high-wear-resistance high-accident-resistance secondary intermediate roll, the overallhardness can reach 80-83 HSD, the overall hardness uniformity is smaller than or equal to 1 HSD, the service life is long, and the accident resistance is improved by 1.5 times or above compared with that of a traditional roll.