The invention discloses a pile main bolt manufacturing technique of a million kilowatt grade nuclear power station. The manufacturing technique includes material-selecting, melting, heating, forging, cooling, after-forging heat treatment, defect-detecting, and forging capability heat treating. When selecting the material, the microelement content of the materials is controlled, the heat preserving duration in the intermediate temperature stage is prolonged, the heat raising and the heat preserving duration in the high temperature stage are reduced, the distortion volume in the course of the forging is controlled between 30 percent and 70 percent, the forging rate reaches 5 above; after-forging heat treatment, ultrasonic defect detecting, and forging capacity heat treating are conducted when the forging is finished. The main bolt produced according to the manufacturing technique of the invention can improve the impact value under the circumstance that the intensity keeps unchanged, theproduct can meet the RCC-M standard requirements completely, and the reliability and the safety of the pile pressure container using the main bolt of the million kilowatt grade nuclear power station can be ensured.