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47results about How to "Reduce carcinogenicity" patented technology
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Method for processing cured fish
The invention discloses a method for processing cured fish, which comprises the following steps: removing internal organ and fish gills of the fresh fish, cleaning the fish and immersing the fish in the Chinese herbal medicine concentrate, brining, preparing ingredient, preserving, air drying, airing and other steps. Compared with the cured fish processed by traditional method, the cured fish has the advantages of unique local flavor, novel mouthfeel, abundant abundant nutrition, health safety and Chinese herbal medicine component-rich, and is suitable to people of all ages.
Owner:ANHUI WANGJIABA ECOLOGICAL AGRI
Organometallic catalyst and preparation thereof
InactiveUS8507708B2Readily availableTime consumingOrganic compound preparationOther chemical processesOrganometallic catalysisSufficient time
The present invention relates to a method for producing an organometallic catalyst and an organometallic catalyst when produced by the method. The method comprises the steps of combining a polycarboxylic acid or anhydride and a metal-oxide, metal-hydroxide or metal-salt with a solvent at a temperature and pressure at which the solvent exists as a supercritical or near-critical fluid. The polycarboxylic acid or anhydride is reacted with the metal-oxide, metal-hydroxide or metal-salt for sufficient time and under sufficient temperature and pressure to produce the organometallic catalyst. The present invention also relates to a process for making a poly(alkylene carbonate) in the presence of a catalytic amount of the organometallic catalyst produced by the method.
Owner:THE UNIV OF SYDNEY
Multifunctional vegetable juice and method for making same
The multifunctional vegetable juice is produced through blending cabbage juice, turnip juice and pork bone soup. During the production, cabbage and turnip are squeezed separately to obtain cabbage juice and turnip juice; pork bone, soybean, ginger, cassia and water are stewed to obtain soup and the soup is seasoned with salt and sugar; and cabbage juice and turnip juice are blended into soup to obtain the multifunctional vegetable juice. The multifunctional vegetable juice connects vitamin A, vitamin C, vitamin U, amino acids, glucose, rapin, carotin, calcium, carbohydrate, trace elements, etc. and thus has health care and disease preventing and treating effect.
Owner:胡佐满 +4
Efficient genetic-modification-free iPSC induced and industrialized monoclonal picking platform and application
ActiveCN113462638AEasy to operateImprove induction efficiencyGenetically modified cellsUnknown materialsReprogrammingSOX2
The invention discloses an efficient genetic-modification-free iPSC induced and industrialized monoclonal picking platform and application. The platform can efficiently perform reprogramming and only needs to use a minimum number of reprogramming factors (OCT4, SOX2, E6 and E7). In a monoclonal separation stage, SSEA4 / TRA-1-60 is taken as a selection marker, a large number of single cell clones are obtained through a flow cytometry sorting technology. The platform has the advantages of being high in reprogramming efficiency, high in safety, easy to operate, capable of achieving large-scale production and the like.
Owner:CHENGNUO REGENERATIVE MEDICINE TECH (ZHUHAI HENGQIN NEW AREA) CO LTD
Methods and compositions for oral delivery of Areca and mate' or theobromine
InactiveUS20050089584A1Enhancing and reducing physiological effectReduce the amount requiredBiocideOrganic chemistryMedicineTheobromine
The present invention comprises methods and compositions comprising Areca extract compositions and compositions comprising extracts of Ilex paraguariensis or theobromine. Methods of the invention comprise methods of making pharmaceutical or nutriceutical products comprising Areca catechu extract compositions and mate' extract compositions or theobromine, and methods of use of the extracted products and pharmaceutical and nutriceutical products. The present invention also comprises methods for treating conditions related to mental and physical fatigue and obesity, as well as, enhancement of mental focus, cognition, and a sense of well being, comprising administering the compositions of the present invention.
Owner:HERBALSCIENCE NUTRACEUTICALS INC
Method for increasing the efficiency of inducing pluripotent stem cells
ActiveUS20130302893A1Improve efficiencyGood effectGenetically modified cellsCulture processStem like cellMolecular biology
The present invention relates to a method for increasing the efficiency of inducing pluripotent stem cells, and more particularly, to a method for increasing the efficiency of inducing pluripotent stem cells by utilizing genes Jhdm1b and Jhdm1a that modify histone. By utilizing Jhdm1b, Jhdm1a, and a stem cell inducing factor, the present invention increases the efficiency of inducing pluripotent stem cells and increases the quality of induced pluripotent stem cells. The stem cell inducing factor is a combination of Oct4 and Klf4, or a combination of Sox2, Oct4, and Klf4, or a combination of Oct4 and Sox2, and Oct4 alone. The method of the present invention further comprises exposing the cells to vitamin C, which further increases the efficiency of inducing pluripotent stem cells as compared with the case where no vitamin C is used. By using less stem cell reducing factors, the method of the present invention reduces the potential carcinogenicity, obtains a high inducing efficiency, and provides high-quality induced pluripotent stem cells capable of germ-line transmission.
Owner:HEFEI CASTEM CELL & REGENERATIVE MEDICINE CO LTD
Preparation method of polytetrafluoroethylene packed dispersion resin
ActiveCN111234269ANarrow particle size distributionImprove liquidityTetrafluoroethylenePolymer science
The invention provides a preparation method of polytetrafluoroethylene packed dispersion resin. The method comprises the following steps: mixing the filler dispersion liquid with the polytetrafluoroethylene dispersion emulsion; uniform stirring the mixture, modulating the system temperature, adding a condensing agent, stirring the mixture until demulsification is started, adding a non-water-soluble fluorine-containing organic solvent which is a hydrogen-containing fluorocarbon (HFC type), perfluoroalkyl ether (PFAE type) or hydrofluoroether (HFE type) solvent, performing coagulation, and filtering, washing and drying the coagulated product to obtain the polytetrafluoroethylene packed dispersion resin. The polytetrafluoroethylene packed dispersion resin is uniform in filling, narrow in particle size distribution, good in fluidity, small in extrusion pressure and convenient to form and process. The preparation method is green, environmentally friendly and safe.
Owner:SHANDONG DONGYUE POLYMER MATERIAL
Method for improving inductive generation efficiency of induced pluripotent stem cells
InactiveCN103173490AImprove efficiencyQuality improvementVector-based foreign material introductionForeign genetic material cellsHuman Induced Pluripotent Stem CellsKLF4
The invention relates to a method for improving the inductive generation efficiency of induced pluripotent stem cells, and especially relates to a method for improving the inductive generation efficiency of the induced pluripotent stem cells through using modified histone gene jhdm1a. Jhdm1a and a stem cell induction factor are utilized to improve the induction efficiency and the induction quality of the induced pluripotent stem cells. The stem cell induction factor can be an Oct4 and Klf4 combination, or an Sox2, Oct4 and Klf4 combination, or an Oct4 and Sox2 combination, or individual Oct4. The method also comprises a step that the cells are exposed to vitamin C, so the induction efficiency of the induced pluripotent stem cells is higher than that of methods which do not use vitamin C. The method uses less stem cell induction factor, so the latent carcinogenicity is reduced, a high induction efficiency is obtained, and the induced pluripotent stem cells having a reproduction system transmission capability and a high quality can also be obtained.
Owner:GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
Organometallic catalyst and preparation thereof
InactiveUS20110319645A1Readily availableTime consumingOrganic compound preparationOther chemical processesOrganometallic catalysisSufficient time
The present invention relates to a method for producing an organometallic catalyst and an organometallic catalyst when produced by the method. The method comprises the steps of combining a polycarboxylic acid or anhydride and a metal-oxide, metal-hydroxide or metal-salt with a solvent at a temperature and pressure at which the solvent exists as a supercritical or near-critical fluid. The polycarboxylic acid or anhydride is reacted with the metal-oxide, metal-hydroxide or metal-salt for sufficient time and under sufficient temperature and pressure to produce the organometallic catalyst. The present invention also relates to a process for making a poly(alkylene carbonate) in the presence of a catalytic amount of the organometallic catalyst produced by the method.
Owner:THE UNIV OF SYDNEY
Antitumor strong medicine and preparation method thereof
InactiveCN102247479AAnti-inflammatoryAnti-allergicPill deliveryGranular deliveryBarbed Skullcap HerbCancer cell
The invention discloses an antitumor strong medicine, which is prepared from barbed skullcap herb, oldenlandia diffusa, berchemia lineate and the like and can be added with filler or solution which is in accordance with medicinal standards to form solid preparation or liquid preparation in pharmacy. The antitumor strong medicine applies tonification and purgation in combination, addresses both root causes and symptoms, removes swelling and stasis, conducts the functions of tonifying yin and blood, restores pulse by tonifying qi and regulates immune system of the human body, and has effects ofresisting tumor, keeping smoothness of detoxification channels and suppressing the growth of cancer cells.
Owner:广西壮族自治区民族医药研究院
Methods and compositions for oral delivery of Areca and mate' or theobromine
The present invention comprises methods and compositions comprising Areca extract compositions and compositions comprising extracts of Ilex paraguariensis or theobromine. Methods of the invention comprise methods of making pharmaceutical or nutriceutical products comprising Areca catechu extract compositions and maté extract compositions or theobromine, and methods of use of the extracted products and pharmaceutical and nutriceutical products. The present invention also comprises methods for treating conditions related to mental and physical fatigue and obesity, as well as, enhancement of mental focus, cognition, and a sense of well being, comprising administering the compositions of the present invention.
Owner:HERBALSCIENCE NUTRACEUTICALS INC
Composition for preventing lung cancer and its preparation method and application
InactiveCN102258676AReduce carcinogenicityPrevention is effectiveRespiratory disorderDermatological disorderSalvia miltiorrhizaLung cancer
The invention relates to a composition for preventing lung cancer, of which the effective medicinal components are prepared from the following medicinal raw materials in parts by weight: 5-8 parts of red ginseng, 10-14 parts of ophiopogon root, 5-7 parts of magnolia vine fruit, 7-9 parts of caterpillar fungus, 8-12 parts of astragalus root, 12-18 parts of oldenlandia diffusa and 9-11 parts of redsage root. The invention also relates to a preparation method of the composition for preventing lung cancer, and application of the composition for preventing lung cancer in preparing a medicament for preventing lung cancer and as a radioprotectant for radon and daughters thereof.
Owner:张蓉
Method for constructing LQT disease model and application of LQT disease model in drug screening
InactiveCN104726492AThe potential of large cell therapyEfficient manufacturingMicrobiological testing/measurementVector-based foreign material introductionCardiac muscleSomatic cell
The invention provides a method for constructing an LQT disease model and application of the LQT disease model in drug screening. The method comprises the following steps: (1) introducing a reprogramming factor coding gene into somatocytes carrying LQTS related mutant gene by using an attachment vector to obtain induced pluripotent stem cells; and (2) under the conditions suitable for differentiation of the induced pluripotent stem cells, culturing the induced pluripotent stem cells to obtain myocardial cells, wherein the myocardial cells constitute the LQTS disease model. The method can be utilized to quickly and effectively prepare the LQTS disease model.
Owner:SHENZHEN SANQI BIOTECH +1
Flax cerebroside compound and extraction and separation method thereof
ActiveCN103087119ABiologically activeGrowth inhibitionSugar derivativesSteroidsSilica gelDrug biological activity
The invention belongs to the field of plant science, and provides a novel flax cerebroside compound and a method for extracting the compound from radishes and radish stems and leaves. The compound is separated and purified mainly by using chromatographic techniques such as silica-gel column chromatography, and methanol extracts of Weixian county radishes and radish stems and leaves are subjected to chemical component separation and purification, and the compound obtained by separation is structurally identified as a novel flax cerebroside compound in the aspects of physical and chemical properties, MS and NMR and the like; and the compound is separated from land plants firstly, and also separated from radishes and radish stems and leaves which are frequently eaten by people for the first time, and therefore, the compound has various important biological activities and important economic and social significances.
Owner:李桂凤
Plant growth accelerator
InactiveCN103420708APromote crop growthLow priceFertilizer mixturesMethionine biosynthesisHumic acid
The invention discloses a plant growth accelerator, relates to an additive and belongs to the technical field of fertilizer. The plant growth accelerator is characterized by comprising the following bulk drugs by weight: 3.8-4.2% of ferrous sulfate, 7.1-7.6% of copper sulfate, 3.2-3.5% of zinc sulfate, 0.0018-0.0022% of iodized salt, 0.0031-0.0036% of selenium salt, 0.013-0.016% of cobalt salt, 0.16-0.18% of manganese sulfate, 0.55-0.65% magnesium sulfate, 3-5% of lysine, 2-3% of methionine, 8-10% of dried hawthorn, 20-30% of humic acid and 48-56% of calcium carbonate. The invention has the beneficial effects that the growth accelerator is a green fertilizer, enhances disease resistance of crops, improves quality of crops, reduces carcinogenesis of crops to human body, especially reduces nitrite content of vegetables; therefore, the plant growth accelerator is an ideal fertilizer for green food.
Owner:魏攻博
Spicy fish oil hotpot condiment and preparation method thereof
InactiveCN106376903AHigh in calciumReduce carcinogenicityFood ingredient as colourFood ingredient as taste affecting agentFish oilFishery
The invention discloses spicy fish oil hotpot condiment and a preparation method thereof. The spicy fish oil hotpot condiment is prepared from the following ingredients (by weight): 90-120 parts of fish oil, 10-20 parts of thick broad-bean sauce, 10-30 parts of chilli, 8-10 parts of Chinese prickly ash, 3-5 parts of ginger, 2-3 parts of garlic, 0.3-0.5 part of anise, 0.2-0.3 part of cassia, 0.2-0.3 part of bay leaf, 0.1-0.2 part of neolitsea ellipsoides allen, 0.2-0.3 part of rhizoma kaempferiae, 0.3-0.8 part of common fennel fruit, 0.2-0.3 part of cardamom, 0.3-0.8 part of tsaoko fruit, 0.3-0.8 part of clove, 0.3-0.8 part of villous amomum fruit, 0.2-0.5 part of cape jasmine, 0.4-0.6 part of licorice, 0.2-0.5 part of dried orange peel, 0.5-1 part of liquor, 0.5-1 part of rock sugar, 1-3 parts of fermented soya bean, 0.5-2 parts of radix platycodi, 1-2 parts of herba lopatheri, 0.8-1 part of Chinese olive and 0.4-0.8 part of exocarpium citri rubrum. The product has red and bright color and rich mouthfeel, whets appetite, is tasty and has endless aftertaste.
Owner:叶吉生
Method for increasing the efficiency of inducing pluripotent stem cells
ActiveUS20140193912A1Reduce in quantityEasy to operateGenetically modified cellsCulture processSOX2Gene
The present invention relates to a method for increasing the efficiency of inducing pluripotent stem cells by utilizing genes Jhdm1a that modify histone. By utilizing Jhdm1a, and a stem cell inducing factor, the present invention increases the efficiency of inducing pluripotent stem cells and increases the quality of induced pluripotent stem cells. The stem cell inducing factor is a combination of Oct4 and Klf4, or a combination of Sox2, Oct4, and Klf4, or a combination of Oct4 and Sox2, and Oct4 alone. The method further comprises exposing the cells to vitamin C, which further increases the efficiency of inducing pluripotent stem cells as compared with the case where no vitamin C is used. By using less stem cell reducing factors, the method of the present invention reduces the potential carcinogenicity, obtains a high inducing efficiency, and provides high-quality induced pluripotent stem cells capable of germ-line transmission.
Owner:HEFEI CASTEM CELL & REGENERATIVE MEDICINE CO LTD
Haematococcus pluvialis astaxanthin milk and preparation method thereof
The invention discloses haematococcus pluvialis astaxanthin milk and a preparation method thereof. Haematococcus pluvialis astaxanthin oil emulsion is added to standard milk fluid, carboxymethyl cellulose is added, the haematococcus pluvialis astaxanthin milk is obtained, haematococcus pluvialis water-soluble astaxanthin is added to the standard milk fluid, the carboxymethyl cellulose is added, and the haematococcus pluvialis astaxanthin milk is obtained. The haematococcus pluvialis astaxanthin milk disclosed by the invention has the efficacy of resisting oxidation, can improve the activity of beneficial microorganisms of intestinal tracts, can reduce the carcinogenecity of aflatoxins, can restrain bladder cancer and colon cancer, can enhance the immune competence of bodies, can promote splenocyte to produce antibodies, can strengthen the effects of T cells, can stimulate the production of immunoglobulin in the bodies, has the effects of beautifying faces and nourishing faces, can prevent retina oxidization, can repair the microcirculation of eye regions and can protect retina.
Owner:HANGZHOU XINWEI LOW CARBON TECH R&D
Method for increasing the efficiency of inducing pluripotent stem cells
InactiveUS9163218B2Reduce in quantityEasy to operateGenetically modified cellsCulture processVitamin CVitamin
The present invention relates to a method for increasing the efficiency of inducing pluripotent stem cells by utilizing genes Jhdm1a that modify histone. By utilizing Jhdm1a, and a stem cell inducing factor, the present invention increases the efficiency of inducing pluripotent stem cells and increases the quality of induced pluripotent stem cells. The stem cell inducing factor is a combination of Oct4 and Klf4, or a combination of Sox2, Oct4, and Klf4, or a combination of Oct4 and Sox2, and Oct4 alone. The method further comprises exposing the cells to vitamin C, which further increases the efficiency of inducing pluripotent stem cells as compared with the case where no vitamin C is used. By using less stem cell reducing factors, the method of the present invention reduces the potential carcinogenicity, obtains a high inducing efficiency, and provides high-quality induced pluripotent stem cells capable of germ-line transmission.
Owner:HEFEI CASTEM CELL & REGENERATIVE MEDICINE CO LTD
Application of magnetic separation filter in killing chironomus larvas in water
InactiveCN101381132AReduce volumeSmall footprintWater/sewage treatment by magnetic/electric fieldsVolumetric Mass DensityImpurity
The invention relates to the technical field of insect killing, in particular to application of a magnetic separation filter to the killing of Chironomus larvas in water. The method for killing the Chironomus larvas in the water by the magnetic separation filter mainly comprises the following processing step of making the water to be treated flow over the magnetic separation filter with the flux density between 4,000 and 6,000 at the speed of between 10 and 60 meters per hour. The method utilizes the characteristic of capability of killing the Chironomus larvas in the water of the magnetic separation filter, skillfully applies the characteristic to the water treatment technique, kills the Chironomus larvas while separating and filtering impurities, and has the advantages of simple equipment, compact structure, small occupied space, high filtering velocity, low energy consumption, easiness in realizing automation and so on.
Owner:GUANGZHOU UNIVERSITY
Radiation resistant composition, wire and cable
ActiveUS8076408B2Reduce carcinogenicityImprove efficiencyRubber insulatorsLiquid organic insulatorsCross-linkRadiation resistant
A radiation resistant composition includes 100 parts by weight of a polymer, 5 to 80 parts by weight of an aromatic series process oil that a polycyclic aromatic (PCA) extract by an IP 346 method (DMSO extraction) is not more than 3% and an aromatic compound content is not less than 20% by a Kurtz analysis, and a radiation resistance imparting agent. The polymer is cross-linked or vulcanized. A wire or a cable includes an insulation and / or a sheath material including the radiation resistant composition.
Owner:HITACHI METALS LTD
Staphylococcus xylosus a2 can convert metmyoglobin to produce new uses of nitrosomyoglobin
ActiveCN103436576BReduce usageReduce carcinogenicityMicroorganism based processesFermentationMicroorganismNitrite
The invention provides novel application of staphylococcus xylosus A2 in conversion of metmyoglobin into nitrosomyoglobin, which belongs to the technical field of food science / meat science and relates to application of the staphylococcus xylosus A2. Substitution of addition of nitrite into a meat product with microbial fermentation belongs to a brand new research field; the invention provides a staphylococcus xylosus A2 stain capable of converting metmyoglobin into nitrosomyoglobin, the strain can convert metmyoglobin into nitrosomyoglobin, i.e., a red pigment for salted meat, in an MSA medium, so a feasible approach is provided for substitution of addition of nitrite into the meat product with microbial fermentation. The staphylococcus xylosus A2 is capable of converting metmyoglobin into nitrosomyoglobin, i.e., the red pigment for salted meat. Thus, fermentation by the staphylococcus xylosus A2 is used to replace addition of nitrite into the meat product for color generation, the usage amount of nitrite is decreased, and potential oncogenicity of the meat product is reduced.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
Method for improving inductive generation efficiency of induced pluripotent stem cells
InactiveCN103173490BImprove efficiencyQuality improvementVector-based foreign material introductionForeign genetic material cellsHuman Induced Pluripotent Stem CellsKLF4
The invention relates to a method for improving the inductive generation efficiency of induced pluripotent stem cells, and especially relates to a method for improving the inductive generation efficiency of the induced pluripotent stem cells through using modified histone gene jhdm1a. Jhdm1a and a stem cell induction factor are utilized to improve the induction efficiency and the induction quality of the induced pluripotent stem cells. The stem cell induction factor can be an Oct4 and Klf4 combination, or an Sox2, Oct4 and Klf4 combination, or an Oct4 and Sox2 combination, or individual Oct4. The method also comprises a step that the cells are exposed to vitamin C, so the induction efficiency of the induced pluripotent stem cells is higher than that of methods which do not use vitamin C. The method uses less stem cell induction factor, so the latent carcinogenicity is reduced, a high induction efficiency is obtained, and the induced pluripotent stem cells having a reproduction system transmission capability and a high quality can also be obtained.
Owner:GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
Antitumor strong medicine and preparation method thereof
InactiveCN102247479BAnti-inflammatoryAnti-allergicPill deliveryCapsule deliveryBarbed Skullcap HerbCancer cell
The invention discloses an antitumor strong medicine, which is prepared from barbed skullcap herb, oldenlandia diffusa, berchemia lineate and the like and can be added with filler or solution which is in accordance with medicinal standards to form solid preparation or liquid preparation in pharmacy. The antitumor strong medicine applies tonification and purgation in combination, addresses both root causes and symptoms, removes swelling and stasis, conducts the functions of tonifying yin and blood, restores pulse by tonifying qi and regulates immune system of the human body, and has effects ofresisting tumor, keeping smoothness of detoxification channels and suppressing the growth of cancer cells.
Owner:广西壮族自治区民族医药研究院
A kind of preparation method of filling polytetrafluoroethylene dispersion resin
The invention provides a preparation method of filled polytetrafluoroethylene dispersion resin, comprising the following steps: mixing the filler dispersion liquid with polytetrafluoroethylene dispersion emulsion, stirring evenly, adjusting the temperature of the system, adding a coagulating agent, and stirring until starting When breaking the emulsion, add a non-water-soluble fluorine-containing organic solvent for coagulation, and then filter, wash, and dry to obtain a polytetrafluoroethylene-filled dispersion resin. The non-water-soluble fluorine-containing organic solvent is a hydrogen-containing fluorocarbon (HFCs), perfluoroalkyl ethers (PFAEs) or hydrofluoroethers (HFEs) solvents. The filled polytetrafluoroethylene dispersion resin prepared by the invention has uniform filling, narrow particle size distribution, good fluidity, low extrusion pressure and is convenient for molding and processing. The preparation method of the invention is environmentally friendly and safe.
Owner:SHANDONG DONGYUE POLYMER MATERIAL
A whitening composition, its preparation method and use
ActiveCN106317952BNo carcinogenic effectNo pollution in the processFibre treatmentNon-macromolecular organic additionAluminium chlorideWhitening Agents
Owner:CHINA TOBACCO FUJIAN IND
Recombinant adenovirus expressing mycoplasma hyopneumoniae P102 protein and applications thereof
InactiveCN101659954BStimulate immune protectionImprove stabilityAntibacterial agentsGenetic material ingredientsBacteroidesBALB/c
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Molecular marker related to lung cancer proliferation and metastasis and application thereof
ActiveCN113293208AImprove expression levelReduce carcinogenicityMicrobiological testing/measurementAntineoplastic agentsOncologyCancer research
The invention provides a molecular marker related to lung cancer proliferation and metastasis and application of the molecular marker. A gene editing technology CRISPR / Cas9 system is adopted, it is found that in a human lung cancer cell line, the TMEM116 gene is closely related to metastasis and proliferation of lung cancer, the TMEM116 gene knockout sgRNA is designed, and the lung cancer cell line with the TMEM116 gene knocked down is obtained through a lipid transfection method. On the basis, in-vitro and in-vivo experiments of mice find that the carcinogenic ability and the metastasis ability of TMEM116 knocked-down lung cancer cells are obviously reduced, the relationship between the TMEM116 gene and the lung cancer is clarified, the TMEM116 gene is found to be used as a molecular marker related to lung cancer proliferation and metastasis and used for diagnosis of the lung cancer, and a new method is provided for diagnosis and treatment of the lung cancer.
Owner:CHINA AGRI UNIV
Lactobacillus flexure r5 capable of converting metmyoglobin to generate oxymyoglobin and use thereof
ActiveCN103555605BReduce usageReduce carcinogenicityBacteriaMicroorganism based processesMicroorganismNitrite
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
Molecular markers related to proliferation and metastasis of lung cancer and their application
ActiveCN113293208BImprove expression levelReduce carcinogenicityMicrobiological testing/measurementAntineoplastic agentsTreatment of lung cancerOncology
The invention provides molecular markers related to proliferation and metastasis of lung cancer and application thereof. The present invention adopts the gene editing technology CRISPR / Cas9 system. In human lung cancer cell lines, it is found that TMEM116 gene is closely related to the metastasis and proliferation of lung cancer. Lung cancer cell lines. On this basis, through in vitro and in vivo experiments in mice, it was found that the oncogenic ability and metastatic ability of lung cancer cells knocked down by TMEM116 were significantly reduced, the relationship between TMEM116 gene and lung cancer was clarified, and TMEM116 gene was found to be an important factor for the proliferation and metastasis of lung cancer. Related molecular markers are used in the diagnosis of lung cancer, and provide a new method for the diagnosis and treatment of lung cancer.
Owner:CHINA AGRI UNIV
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