The invention discloses an automated mask management system and method. The system comprises a production management module, a mask management module, a process execution module, a mask processing module and a mask storage module, wherein the production management module can be in data interaction with the mask management module, the process execution module, the mask processing module and the mask storage module respectively through an EAP (Equipment Automatic Program) and a server. According to the system and the method, disclosed by the invention, a mask can be accurately applied to a corresponding photoetching machine, a corresponding photoetching process and a corresponding photoetching product, so that the error ratio caused by human factors is reduced, the range of influence caused after problems occur is reduced, the use conditions of the mask can be effectively monitored, and the mask trace tracking is facilitated; and thus, the subsequent data analysis is facilitated, the feedback speed is accelerated, and then, the management is timesaving and laborsaving, so that the process production cost is reduced, and the problem of yield caused by human errors is solved.