The invention discloses a 
pleuromutilin derivative containing a 1, 2, 4-
triazole acrylamide side chain as well as a preparation method and application of the 
pleuromutilin derivative, and belongs to the field of medical 
chemistry. According to the compound, 
pleuromutilin and different substituted 
acrylic acid are used as raw materials, 3-sulfydryl-1, 2, 4-
triazole is used as a connector under the action of a catalyst, and the pleuromutilin derivative which is not reported, has the activity of resisting 
drug-
resistant bacteria and contains a 1, 2, 4-
triazole acrylamide side chain is synthesized. The synthesis method is high in 
operation safety, mild in reaction condition and suitable for industrial production. Preliminary 
biological activity tests and safety evaluation show that the pleuromutilin derivative containing the 1, 2, 4-triazole 
acrylamide side chain and having the 
drug-resistant bacterium resisting activity has good 
drug-resistant bacterium resisting activity and safety, so that the pleuromutilin derivative can be applied to treatment of infectious diseases, especially infectious diseases caused by drug-
resistant bacteria, and has good application prospects. The 
medicine development value is very good.