The present application relates to the technical field of
liquid milk production and
processing, and discloses a production method and
system of high-activity immunoglobulin
liquid milk, which comprises the following steps: screening qualified
raw milk and performing milk clarification and
defatting through
enzyme-linked immunosorbent
assay combined with high-performance liquid
chromatography, obtaining defatted milk by dynamically adjusting the centrifugal speed and storing the defatted milk at low temperature, periodically detecting the defatted milk by dynamically regulating the storage temperature, and obtaining qualified defatted milk; extracting immunoglobulin, regulating the subtype ratio of the immunoglobulin to adapt to special medical scenarios, and then performing
glycosylation modification and desensitization, obtaining immunoglobulin modified liquid and sterile substrate through synergistic sterilization treatment; dynamically adjusting the speed for mixing and correcting the physicochemical properties, performing sterile filling and sealing after optimizing the sensory quality, comprehensively detecting the packaged product, and obtaining qualified finished products; dynamically regulating
cold chain parameters according to the activity of immunoglobulin, monitoring the whole process, classifying and stacking, optimizing the adaptability of the production
system, treating production
wastewater, and recycling residual immunoglobulin.