The invention discloses a lotus leaf and jerusalem artichoke wine and a preparation method thereof. The lotus leaf and jerusalem artichoke wine is prepared from lotus leaves, jerusalem artichoke, cane sugar, soybean oligosaccharides, lotus seeds, seaweed, sargassum fusiforme, angel wine yeast, tryptophan, mixed enzyme, lycopene and citric acid. According to the lotus leaf and jerusalem artichoke wine and the preparation method thereof, the method is simple, operation is easy, the cost is saved, the taste is refreshing, the alcoholic strength is low, the sugar content is low, and the wine is clear and transparent and is good in stability. Through enzymolysis, blending and fermentation, lotus leaf alkaloid bioactive constituents of the lotus leaves are dissolved in ethyl alcohol and water in the two states of lotus leaf alkaloid and lotus leaf alkaloid salt, and the extraction rate is high. When the wine is reasonably matched with other food, the health care function can be significantly enhanced, and the lotus leaf and jerusalem artichoke wine can improve sleeping, reduce fat and lose weight, achieve the bacteriostatic and antiviral effect, prevent cardiovascular and cerebrovascular diseases, enhance resistance, resist aging, and achieve the life prolonging effect. The deep processing approach of the lotus leaves and the jerusalem artichoke is added, the utilization rate is improved, and economic incomes of farmers are increased.