The invention relates to a method for preparing a multiple-stimulation respond material by virtue of a two-step process. The method comprises the following steps: putting maleimide into a reaction bottle, adding N,N-dimethylformamide and a halogenating reagent, heating until the temperature reaches 58 DEG C for reacting for 48-72 hours, and adding water and dichloromethane sequentially for suction filtration to obtain 3,4-dihalogenmaleimide; putting 3,4-dihalogenmaleimide and a palladium bis(triphenylphosphine) dichloride catalyst into a flask, vacuumizing, then filling the flask with nitrogen, injecting anhydrous N,N-dimethylformamide and 2-(tributylstannyl)thiophene, increasing the temperature to 100 DEG C for reacting for 12 hours, cooling, then adding the mixed solution of dichloromethane and saturated potassium fluoride aqueous solution, then extracting, drying, filtering and purifying through column chromatography to obtain 3,4-bis(2'-thienyl)maleimide. The material prepared by the method provided by the invention has the advantages of good heat stability, simple synthesis steps, high solid-state fluorescent quantum efficiency and the like, and also has the properties of piezallochromy, thermochromism, solvent induced chromism and the like.