The invention discloses an ointment medicine for treatment of dermatopathy and a preparation method thereof, the ointment medicine comprises the following components by mass: 1-5 parts of cortex dictamni, 1-5 parts of eomecon chionantha, 1-5 parts of raw rhubarb, 1-5 parts of fructus forsythiae, 1-5 parts of fructus kochiae, 1-5 parts of folium artemisiae argyi, 1-5 parts of cortex phellodendri, 1-5 parts of radix sophorae flavescentis, 1-5 parts of fructus cnidii, 1-5 parts of nux vomica, 1-5 parts of periploca forrestii, 1-5 parts of saffron, 1-5 parts of centipede, 1-5 parts of scorpion, 1-5 parts of lithospermum, 1-5 parts of red peony root and 1-5 parts of borneol; the preparation method of the ointment medicine includes the following steps: A, according to the mass ratio, selecting the good-quality cortex dictamni, eomecon chionantha, raw rhubarb, fructus forsythiae, fructus kochiae, folium artemisiae argyi, cortex phellodendri, radix sophorae flavescentis, fructus cnidii, nux vomica, periploca forrestii, saffron, centipede, scorpion, lithospermum, red peony root and borneol to grind into powder respectively; B, filtering the ground powder, putting into a mixer vessel for evenly mixing; C, sterilizing the well mixed powder by ultraviolet; and D, filling appropriate amount of menthol, camphor and chlorhexidine acetate into the mixer vessel in an asepsis room, then pouring the sterilized powder, mixing and packaging.