The invention discloses meal replacement powder, which is prepared from the following raw materials in parts by weight: 15-30 parts of donkey-hide gelatin, 15-30 parts of rhizoma dioscoreae, 15-30 parts of red date, 10-20 parts of small red bean, 10-20 parts of semen euryales, 10-20 parts of black sesame, 10-20 parts of radix angelicae sinensis, 10-20 parts of rose and 10-20 parts of brown sugar.A preparation method comprises the following steps: respectively frying the small red bean, the semen euryales and the black sesame; respectively slicing and drying the rhizoma dioscoreae and the radix angelicae sinensis; denucleating and slicing the red date, and drying at the temperature of 60-80 DEG C for 2-4h; evenly mixing and smashing the above raw materials, the donkey-hide gelatin, the rose and the brown sugar according to a ratio, sieving by a screen of 80-100 meshes, carrying out ultraviolet sterilization, and packaging in a specification of 20g/bag. According to the meal replacementpowder disclosed by the invention, various dietetic traditional Chinese medicines are taken as raw materials, the prepared meal replacement powder has the advantages of good taste, simple edible method, safety, reliability and no toxic or side effect. The meal replacement powder disclosed by the invention has the efficacy on benefiting qi and nourishing blood, also has a good conditioning function on female patients with symptoms including unsmooth qi and blood circulation, dark yellow and loose skin, coarse pore, dryness, alopecia, insomnia, dreamful sleep, cold feet and hands, pro-senescence and the like, and can be taken for a long time.