The invention discloses a preparation process of sini powder, which comprises the following steps: respectively performing decoction on four medicines, namely 40-80 parts of Chinese thorowax root, 40-80 parts of bitter orange stir-fried with bran, 40-80 parts of white paeony root and 40-80 parts of liquoric root, for preparing decoction pieces; respectively extracting the Chinese thorowax root and the white paeony root and respectively concentrating to form concentrated solution with the relative density of 1.05-1.10 for standby; drying and smashing Chinese thorowax root medicine residue, white paeony root medicine residue, the bitter orange stir-fried with the bran and the liquoric root, then laying on a drying tray, placing into a microwave vacuum dryer for drying and sterilization, smashing into very coarse powder, pouring the very coarse powder into a trough type mixing machine, sequentially slowly adding the concentrated solution of the Chinese thorowax root and the white paeony root medicinal materials for mixing, and uniformly mixing; placing the very coarse powder of the medicinal materials mixed with the concentrated solution into the microwave vacuum drying device for drying and sterilization, taking out, and placing into a multifunctional smashing and grading machine for smashing, wherein coarse powder can completely pass through a sieve No. 2 and the powder mixed in the coarse powder, which can pass through a sieve No. 4, does not exceed 20% by weight; and then packaging.