The invention discloses a thermoplastic elastomer refrigerator door sealing strip material and a preparation method. The thermoplastic elastomer refrigerator door sealing strip material is prepared from the following materials of SEPS (hydrogenated styrene-isoprene) and/or SBS (styrene-butadiene-styrene), LLDPE (linear low density polyethylene), regular polypropylene, filling oil, mineral filler,a lubricant, a coupling agent and an antioxidant. The preparation method of the thermoplastic elastomer refrigerator door sealing strip comprises the following steps of weighing, uniformly mixing, granulating, extruding and forming. The thermoplastic elastomer refrigerator door sealing strip has the advantages that the problem in the refrigerator door sealing strip material using PVC (polyvinyl chloride), TPV (thermoplastic vulcanizate) and the like as the substrates on market is solved; the cold-resistant property is good, the elasticity is good, the deformation recovery ability is strong, the sealing effect is good, the non-toxic and environment-friendly effects are realized, and the recycling effect is realized; the hardness range is broad, the anti-crease effect is good, the dry and fresh effects are realized, the hand feel is comfortable, and any foreign odor is avoided.