The invention discloses a high-strength sealing glue for a paper packaging box, which comprises the following components in parts by mass: 30-40 parts of binder, 40-50 parts of plasticizer, 10-20 parts of tackifier, 6-9 parts of wetting agent, 4-5 parts of associated monomer, an appropriate amount of emulsifier, an appropriate amount of preservative, an appropriate amount of initiator and an appropriate amount of deionized water. The binder is formed by compounding butyl acrylate and an EVA (Ethylene-vinyl acetate) emulsion, and two monomers of ethylene and vinyl acetate are subjected to an emulsion polymerization reaction to form a calibration emulsion with the solid content of 50%, i.e., the EVA emulation; and the binder comprises the following components by mass ratio: 50-80 parts of butyl acrylate and 50-20 parts of EVA emulsion. The high-strength sealing glue provided by the invention has the advantages of large early adhesive force, high bonding strength, strong permeability, environmental friendliness, non-volatilization, non-toxicity, tastelessness and the like for a non-polar hard sticky material, at the same time, the production process is simple, the production cost is low, raw materials are easily purchased, no three wastes are generated, no burning danger is generated, the development direction of a high molecular polymer is closely linked, and the urgent needs of the market are met.