The invention provides a high-temperature resistant, anti-sticking and anticorrosive thermoplastic coating for inner walls of metal pipelines and a preparation method thereof, belonging to the technical field of coatings. The coating comprises thermoplastic polyether sulfone resins, high-temperature resistant fluororesins, thixotropic agents, anticorrosion pigments, functional fillers, a complex solvent and auxiliaries in a mass ratio of (10-20):(6-15):(0-2):(2-15):(0-30):(40-78):(0-2). The preparation method is characterized by mixing the thermoplastic polyether sulfone resins, high-temperature resistant fluororesins, thixotropic agents, functional fillers, anticorrosion pigments, complex solvents and auxiliaries and then stirring the mixture at a linear velocity of 15m / s for 15-30 minutes and then sanding the mixture for 2-6 hours. The coating provided by the invention has the characteristics that the coating has good adhesion with metal substrates, has usage temperature up to 260 DEG C, has low surface energy, is oleophobic and lyophobic, prevents contamination and scaling and has strong acid, alkali and corrosion resistance capacities and thin coat. The preparation method is simple, the production process is easy to control and the production equipment is easy to achieve.