The invention discloses a screw pump with low viscosity and high pressure. The screw pump comprises a pump body, a driving screw, a bearing and a sealing structure, wherein the driving screw, the bearing and the sealing structure are arranged in the pump body. A driven screw is further arranged in the pump body. The bearing and the sealing structure are arranged on the driving screw in a sleeving manner. A pump cavity is formed in the pump body, and a bushing is arranged in the pump cavity in the axial direction. The driving screw and the driven screw are arranged in the bushing which is provided with matching holes. The side wall of the driven screw is in engaged fit with the side wall of the driving screw, and the two ends of the side wall of the driven screw are connected with the top inner wall and the bottom inner wall of the pump cavity correspondingly. The bottom of the driving screw is arranged over the bottom inner wall of the pump cavity. The screw pump with low viscosity and high pressure is simple in structure, small in size, compact in layout, convenient to install, durable, resistant to abrasion, high in pressure and low in internal leakage of flow, the abrasion resistance and durability of the engaged screw pair and the surface of the inner wall of the bushing can be effectively enhanced, power energy consumption can be reduced, and the service life can be prolonged.