16 results about "E-polylysine" patented technology

The application discloses a kind of nanoparticles for tumor sonodynamic combined individualized immunotherapy and its preparation method and application, belong to the field of biological medicine.The nanoparticles for tumor sonodynamic combined individualized immunotherapy are double-shell core structure nanoparticles formed by inner core and shell, and the inner core is formed by self-assembly of TLR3 agonist Poly (I:C), L-arginine and polylysine, and the shell is hyaluronic acid layer HA-Ce6 conjugated with photosensitizer Ce6.It is found through experiment verification that the nanoparticles can target tumor, generate reactive oxygen species to kill tumor cells under the action of ultrasound, promote M1 macrophage polarization and produce NO release at the same time, play the role of antitumor and immune effect, and realize the combined application of sonodynamic and NO gas therapy.The nanoparticles for tumor sonodynamic combined individualized immunotherapy can trigger systemic immune response, inhibit primary tumor, produce immune memory effect, and prevent tumor metastasis and recurrence.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The application discloses a bacteriostatic and deodorizing zeolite cat litter and a preparation method thereof, and belongs to the technical field of zeolite cat litter preparation. The bacteriostatic and deodorizing zeolite cat litter is composed of the following components in parts by weight: 55-75 parts of modified zeolite, 3-6 parts of bacteriostatic gel, 2-5 parts of adhesive, and 1-3 parts of filler. The modified zeolite is prepared from sulfamic acid, N,N-dimethylformamide, lignocellulose and zeolite, and the bacteriostatic agent is prepared from four-arm polyethylene glycol, succinic anhydride, triethylamine, N-hydroxyl glutarimide, 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride and polylysine. The zeolite cat litter prepared by the method has excellent water absorption, antibacterial property and deodorizing property.

The invention relates to the technical field of seasonings, and particularly discloses a composite sausage seasoning and a preparation method thereof. The seasoning is prepared from edible salt, isomaltooligosacharide, sodium glutamate, a yeast extract, shiitake mushroom powder, spices, red yeast rice powder, a rosemary extract, nisin, trehalose, curdlan, fermented celery powder, epsilon-polylysine and the like according to a specific ratio. The preparation method comprises the steps of basic raw material mixing, microencapsulation slow-release treatment, stage mixing, spice adding and the like, curdlan is used for embedding the rosemary extract, the slow-release effect is achieved, and a vacuum mixing technology is adopted for ensuring uniformity. The seasoning provided by the invention has synergistic antibacterial and antioxidant properties, can significantly prolong the shelf life of sausages, enhance flavor level and umami strength, maintain salty taste perception while reducing the sodium content, improve the product texture and processing stability, and meet the production requirements of natural and healthy meat products.

The application belongs to the technical field of high polymer substances, and particularly relates to a preparation method of astaxanthin-loaded ovomucin-pectin-epsilon-polylysine hydrochloride composite nanogel. Under stirring conditions, a pectin solution is added into an ovomucin solution; then an astaxanthin solution is added, and ultrasonic treatment is performed to obtain a mixed solution; an epsilon-polylysine hydrochloride solution is added into the mixed solution, and stirring reaction is performed to obtain a mixture; the mixture is centrifuged to obtain a dispersion liquid and a precipitate, and the dispersion liquid is dialyzed after separation to obtain the astaxanthin-loaded ovomucin-pectin-epsilon-polylysine hydrochloride composite nanogel. The application uses naturally-sourced ovomucin, pectin and epsilon-polylysine hydrochloride as raw materials, effectively avoids the use of organic solvents, and reduces the risk of organic residue; the preparation method has mild conditions and simple operation, the raw materials are widely sourced and low in price, and the application does not need complex equipment and organic solvents, and has good prospects for large-scale production and application.

The invention discloses a composite fresh-keeping coating film for refrigeration after lily harvesting and a preparation method of the composite fresh-keeping coating film, and belongs to the technical field of fresh keeping of agricultural products after harvesting. The composite fresh-keeping coating film is prepared from gelatin, chitosan, vitamin C and epsilon-polylysine. According to the method, the composite fresh-keeping coating is directly coated on the surfaces of the lilies in a manner of matching coating fresh-keeping with refrigeration fresh-keeping, so that in a low-temperature and high-humidity environment, pathogenic bacteria aiming at the lilies can be effectively inhibited, and rotting and browning in a refrigeration process are slowed down. And the cleaning agent is easy to clean at normal temperature, safe and residue-free.

The invention discloses a rice husk-based nano antibacterial edible film and a preparation method thereof, and belongs to the technical field of food packaging materials. The edible film comprises the following components: rice hull nanofibers; chitosan is added; plant essential oil; starch; a plasticizer and a compound antibacterial agent. Wherein the grain size of the rice husk nanofibers is 50-900 nm. The compound antibacterial agent is prepared from natamycin and polylysine. Meanwhile, the invention further provides a preparation method of the edible film. The edible film provided by the invention has excellent antibacterial property, mechanical property and barrier property, and is beneficial to prolonging the shelf life of food. Meanwhile, the edible film is made of rice hull fibers, so that the utilization rate of rice hulls can be increased, and environmental pollution caused by rice hull treatment can be reduced.

The invention relates to the technical field of water treatment, and particularly discloses an enzyme-containing acidic cleaning agent for a reverse osmosis and nanofiltration system and a preparation method of the enzyme-containing acidic cleaning agent. An enzyme-containing acidic cleaning agent for a reverse osmosis and nanofiltration system is composed of the following components in percentage by weight: 5-25% of organic acid, 1-5% of a chelating agent, 5% of a stabilizer, 1-5% of biological enzyme, 0.5-3% of a surfactant and the balance of deionized water. The stabilizer is prepared from alanine, trehalose, PEG (Polyethylene Glycol) and epsilon-polylysine, and the mass ratio of the alanine to the trehalose to the PEG to the epsilon-polylysine is 1 to (0.3 to 0.4) to (0.1 to 0.2) to (0.05 to 0.1). The cleaning agent provided by the invention can effectively remove various pollutants such as inorganic salt scales, combinations of iron, aluminum and organic matters, metal oxides, organic matters and microbial slime on the surface of the reverse osmosis membrane or the nanofiltration membrane, and remarkably recovers the flux and the desalination rate of the membrane.

This invention belongs to the field of polymer technology, specifically relating to a method for preparing an astaxanthin-loaded ovomucoid-pectin-ε-polylysine hydrochloride composite nanogel. Under stirring conditions, a pectin solution is added to an ovomucoid solution; then an astaxanthin solution is added, followed by ultrasonic treatment to obtain a mixed solution; an ε-polylysine hydrochloride solution is added to the mixed solution, and the mixture is stirred to obtain a further mixture; the mixture is centrifuged to obtain a dispersion and a precipitate. After separation, the dispersion is dialyzed to obtain the astaxanthin-loaded ovomucoid-pectin-ε-polylysine hydrochloride composite nanogel. This invention uses naturally sourced ovomucoid, pectin, and ε-polylysine hydrochloride as raw materials, effectively avoiding the use of organic solvents and reducing the risk of organic residues. The preparation method is mild, simple to operate, uses widely available and inexpensive raw materials, requires no complex equipment or organic solvents, and has good prospects for large-scale production and application.

The invention belongs to the technical field of biological materials, and particularly relates to an in-situ curable composition, anti-adhesion hydrogel and a preparation method and application thereof. The composition capable of being cured in situ provided by the invention comprises a polyethylene glycol aldehyde derivative solution and a polylysine solution, the mass percentage content of a polyethylene glycol aldehyde group derivative in the polyethylene glycol aldehyde group derivative solution is 5-20%; the mass percentage content of polylysine in the polylysine solution is 4-10%; the molar ratio of the aldehyde group in the polyethylene glycol aldehyde group derivative to the amino group in the polylysine is (0.05-0.2): 1. The composition provided by the invention is composed of the polyethylene glycol aldehyde group derivative and the polylysine with good biocompatibility, the polyethylene glycol aldehyde group derivative and the polylysine can form hydrogel through a Schiff base reaction, the gelation time and the degradation time of the obtained hydrogel meet clinical requirements, and the composition is suitable for different uterine cavity structures due to the characteristics of injectability and in-situ gelling, and can be used for preparing the hydrogel. The effect of preventing postoperative intrauterine adhesion is excellent.

The application discloses a quick-acting hemostatic hydrogel, which comprises microgels and polylysine, and the mass ratio of the microgels to the polylysine is 1:2 to 2:1, and the microgels comprise oxidized methyl methacrylic hyaluronic acid and aqueous polyurethane. The application further discloses a preparation method of the quick-acting hemostatic hydrogel, and a use for hemostasis or preparation of a hemostatic product. The quick-acting hemostatic hydrogel of the application has viscosity and strength, has the performance of quick blood coagulation and hemostasis, and is beneficial to quick hemostasis of different wounds.

The invention discloses a wool fabric finishing agent as well as a preparation method and application thereof, and belongs to the technical field of fabric finishing. The preparation method of the wool fabric finishing agent comprises the following steps: dissolving zein powder in an ethanol water solution to obtain a clear yellow zein solution; sequentially adding genipin and epsilon-polylysine for reaction, and washing and freeze-drying after the reaction to obtain epsilon-polylysine modified blue zein powder; and dissolving the blue protein nano-particles in an ethanol water solution, and slowly adding water while stirring to obtain a blue protein nano-particle suspension, namely the wool fabric finishing agent. The finishing agent can be used for treating the wool fabric to obtain the antibacterial, antioxidant and anti-felting colored wool fabric; the method is simple and easy to operate, energy-saving and environment-friendly, has no toxic effect on a human body, and has potential application value and practical significance.

The invention discloses a composite film with a non-angle-dependent structural color as well as a preparation method and application thereof, and belongs to the field of functional film materials. The invention aims to solve the problem that an integrated film with non-angle-dependent structural color, active antibacterial property, stimulus response and excellent mechanical property is difficult to realize by a CNC film at the same time. The invention discloses a composite film with a non-angle-dependent structural color. The composite film is prepared from cellulose nanocrystals, sorbitol, tannic acid and polylysine, the method comprises the following steps: 1, mixing cellulose nanocrystal suspension and sorbitol; 2, adding tannic acid; 3, adding a polylysine solution; and 4, evaporation-induced self-assembly film formation. The method is applied to anti-counterfeiting materials and intelligent packaging materials.

The invention relates to an oral care composition for freshening breath and maintaining gingival health and application thereof. The oral care composition comprises zinc lactate, zinc citrate, persimmon fruit extract, yeast fermentation product extract and polylysine. According to the invention, multiple active components are reasonably compounded, and the components can play a role from multiple dimensions, so that the effects of freshening breath and maintaining gingival health are synergistically improved.

The present application relates to the technical field of biomaterials, and relates to an in-situ curable reagent composition, an anti-adhesion hydrogel, a preparation method therefor and a use thereof. The in-situ curable reagent composition provided in the present application comprises a polyethylene glycol aldehyde-based derivative solution and a polylysine solution. The mass percentage content of a polyethylene glycol aldehyde-based derivative in the polyethylene glycol aldehyde-based derivative solution is 5-20%; the mass percentage content of polylysine in the polylysine solution is 4-10%; and the molar ratio of aldehyde groups in the polyethylene glycol aldehyde-based group derivative to amino groups in the polylysine is 0.05-0.2:1. The composition provided in the present application is composed of the polyethylene glycol aldehyde-based derivative and the polylysine which have good biocompatibility. The two components can be formed into a hydrogel by means of a Schiff base reaction. The gelation time and degradation time of the obtained hydrogel are adapted to clinical requirements. The characteristics of injectability and in-situ gelation are suitable for different uterine cavity structures, and the postoperative uterine cavity adhesion prevention effect is excellent.

The invention provides a spot-fading preparation for corium layer injection, application of the spot-fading preparation, a whitening and spot-fading composition as well as a use method and application of the whitening and spot-fading composition, and relates to the technical field of cosmetics. Based on the unique performance of silk fibroin, the traditional application scope is broken through, and the effect that the silk fibroin injected into the corium layer can obviously fade existing color spots is disclosed for the first time. The silk fibroin is directly injected into the corium layer, the synergistic interaction effect of sodium hyaluronate is combined, the color spots are remarkably faded, meanwhile, the silk fibroin can be matched with external essence containing sodium hyaluronate, tannic acid and polylysine, a complete skin whitening and spot fading scheme combining injection treatment and postoperative care is formed, and the skin whitening and spot fading effect is good. The invention not only overcomes the defects of poor transdermal absorption and non-lasting effect of the traditional whitening component, but also shows the spot fading effect superior to that of the conventional whitening method through a multi-target action mechanism, has the advantages of good biocompatibility, high safety, wide adaptation disease and the like, and provides a new solution for chloasma, sunburn and other intractable hyperpigmentation problems.