The invention relates to a safe positioning school bus picking system, and the system comprises a cloud control platform, a student sub-terminal, and a school bus safety module. The student sub-terminal and the school bus safety module are in wireless communication connection with the cloud control platform. The cloud control platform comprises a processor, a positioning detection module, a first communication module, a human face recognition database, a safety prompt module, an alarm module, a data storage module, and a comparison module. The human face recognition database is used for storing the face data of students, parents, a school bus driver and a conductor, and updates the face data of persons wanted by the Ministry of Public Security. The student sub-terminal comprises a radio frequency module and a second communication module. The school bus is provided with a positioning module, thereby facilitating the timely obtaining of the running path and state of the school bus, and facilitating the processing of emergency. The first and second radio frequency induction modules are used for sensing the student sub-terminal. The human face recognition module carries out human face recognition, and effectively prevents the possible leaked picking or wrong picking.