The invention discloses a mirror surface region protection method of a COB mirror surface aluminum base plate, which comprises the following steps: step 1, preparing heat resistant glue: respectively weighing the following components in parts by weight: 60-65 parts of VAGH, 18-22 parts of curing agent, 8-10 parts of phthalate, 2-5 parts of lubricant and 2.5-5 parts of pigment system; heating the VAGH, curing agent and phthalate to 55-65 DEG C, stirring uniformly, then adding the lubricant and the pigment system, after fully stirring and cooling to room temperature to obtain the heat resistant glue; step 2, screen printing: by enabling a prepared screen to correspond to a mirror surface region of the COB mirror surface aluminum base plate, printing the heat resistant glue, and baking; step 3, reflow soldering: performing hot air reflow soldering on the COB mirror surface aluminum base plate; step 4, film tearing: after the reflow soldering is finished, manually tearing a protection film. By performing screen printing of the heat resistant glue in the mirror surface region, during reflow soldering, the mirror surface region is effectively protected.