The invention discloses a support-matched large component powder injection molding method. The method comprises the following steps that a, metal powder and a binder are mixed uniformly and then prepared into feed particles; b, an injection molding machine is utilized for injecting the feed particles into a mold to form a blank; c, a support matched with the shape of the blank is pressed and molded, and a separation coating is brushed on the surface of the support; and d, after the blank is put on the surface of the support, the blank and the support are put in a sintering furnace together for degreasing and sintering, and sintering is completed to obtain a finished product. In the sintering step in the injection molding process, the blank is put on the support, the separation coating is brushed between the blank and the support, feed parameters and molding parameters are adjusted, then the blank and the support are sintered together, and it is guaranteed that the shrinking rates of the blank, the separation coating and the support during sintering are consistent; and meanwhile, the blank, the separation coating and the support are combined closely, the shapes are matched, no clearance exists between the blank, the separation coating and the support, no crack is generated to the blank during sintering, and the percent of pass and quality of the finished product are effectively improved.