The invention discloses a small molecular
organic compound with a specific targeting TSPO (Transfer
Protein). The structure of the small molecular
organic compound comprises a
benzene ring, pyrazolo
imidazole and a diethyl
acetamide structure. The P-toluenesulfonyl on a
side chain of a
benzene ring is used as a marker site; carrier-free radioactive
fluorine-18 is used as a
radioactive source; andmild alkaline
reaction conditions are designed and utilized. By using a functional GE TRACERlab FX2N synthesizer, a target compound [18F] DPA714 is obtained through a one-step reaction. The method hasthe advantages of mild
reaction conditions, simple steps, and automatic labeling; the non-attenuation correction yield reaches 40% or above; the radiochemical purity of the product is higher than 99%, the
specific activity is higher than 148GBq / [mu] mol (4Ci / [mu] mol). The invention solves the technical problems of low labeling yield, low
specific activity, complex operation and the like in the prior art. A radioactivity
molecular probe prepared from the small molecular compound is shown as an imaging
evaluation result of a
positron emission
tomography (PET) in patients (including Alzheimer'sdisease and cerebral apoplexy) with
neuroinflammation related diseases, and the radioactivity
molecular probe has the characteristics of high sensitivity, high sensitivity, high sensitivity, high sensitivity, high sensitivity, high sensitivity and the like. It is proved that the
molecular probe has good specificity, targeting, stability and non-
target tissue clearance rate.